Publications

133   Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. Modulating NRF2 in Disease: Timing Is Everything. Annu Rev Pharmacol Toxicol. 2018 Sep 26. PMID:30256716

132   Liu P, Rojo de la Vega M, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JGN, Zhang DD. 2. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44). PMID:30309964

131   Yang Y, Kong S, Zhang Y, Melo-Cardenas J, Gao B, Zhang Y, Zhang DD, Zhang B, Song J, Thorp E, Zhang K, Zhang J, Fang D. The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice. J Biol Chem. 2018 Aug 17;293(33):12934-12944. PMID:29907570

130   Wei J, Yuan Y, Xu Y, Chen L, Zhang Y, Wang Y, Yang Y, Peek CB, Diebold L, Yang Y, Gao B, Jin C, Melo-Cardenas J, Chandel NS, Zhang DD, Pan H, Zhang K, Wang J, He F, Fang D. ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes. Nat Commun. 2018 Sep 10;9(1):3659. PMID:30201971

129   Ray S, Corenblum MJ, Anandhan A, Reed A, Ortiz FO, Zhang DD, Barnes CA, and Madhavan L. 2018. A role for Nrf2 expression in defining the aging of hippocampal neural stem cells. Cell transplantation. Cell Transplant. 2018 Apr;27(4):589-606. PMID:29871525

128   Rojo de la Vega M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018 Jul 9;34(1):21-43. PMID:29731393

127   Rojo de la Vega M, Zhang DD. NRF2 Induction for NASH Treatment: A New Hope Rises. Cell Mol Gastroenterol Hepatol. 2018 Jan 10;5(3):422-423. doi: 10.1016/j.jcmgh.2017.12.009. eCollection 2018 Mar. No abstract available. PMID:29675456

126   Rojo de la Vega M, Zhang DD*, Wondrak GT*. Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Front Pharmacol. 2018 Mar 27;9:287. doi:10.3389/fphar.2018.00287. eCollection 2018. PMID:2963669

125   Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD. Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol. 2018 Mar 5.pii: MCB.00595-17. doi: 10.1128/MCB.00595-17. [Epub ahead of print] PMID:29507186

124   Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol. 2018 Feb 15;341:106-113. doi: 10.1016/j.taap.2018.01.014. Epub 2018 Feb 3. PMID:29408041

123   Rojo de la Vega M, Krajisnik A, Zhang DD, Wondrak GT. Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients. 2017 Dec 18;9(12). pii: E1371. doi:10.3390/nu9121371. Review. PMID:29258247

122:  Wang S, Xiao Y, Zhang DD, Wong PK. Non-Canonical activation of NRF2: A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells. Biomaterials. 2018 Feb;156:56-64. doi: 10.1016/j.biomaterials.2017.11.026. Epub 2017 Nov 24. PMID:29190498.

121:  Tian W, Rojo de la Vega M, Schmidlin CJ, Ooi A, Zhang DD. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2). J Biol Chem. 2018 Feb 9;293(6):2029-2040. doi: 10.1074/jbc.RA117.000428. PMID:29255090.

120:  Rojo de la Vega M, Krajisnik A, Zhang DD, Wondrak GT. Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients. 2017 Dec 18;9(12). pii: E1371. doi: 10.3390/nu9121371. Review. PMID: 29258247

119   Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Review. PMID: 28985560.

118:  Dodson M, Zhang DD. Non-Canonical activation of NRF2: New insights and its relevance to disease. Curr Pathobiol Rep. 2017 Jun;5(2):171-176. doi: 10.1007/s40139-017-0131-0. Epub 2017 Apr 19. PMID:29082113.

117:  Wang S, Sun J, Xiao Y, Lu Y, Zhang DD, Wong PK. Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling. Advanced Biosystems. 2017 Jan. 31. doi: 10.1002/adbi.201600019.

116:  Tao S, de la Vega MR, Chapman E, Ooi A, Zhang DD. The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. Mol Carcinog. 2018 Feb;57(2):182-192. doi: 10.1002/mc.22745. Epub 2017 Nov 6. PMID:28976703.

115:  Long M, Li X, Li L, Dodson M, Zhang DD, Zheng H. Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. Trends Endocrinol Metab. 2017 Nov;28(11):818-830. doi: 10.1016/j.tem.2017.09.001. Epub 2017 Sep 28. Review. PMID:28966079.

114:  Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. doi: 10.1016/j.bmcl.2017.07.045. Epub 2017 Jul 19. PubMed PMID:28757063.

113:  Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD*, Chapman E. Arsenic Compromises Both p97 and Proteasome Functions. Chem Res Toxicol. 2017 Jul 17;30(7):1508-1514. doi: 10.1021/acs.chemrestox.7b00158. Epub 2017 Jul 7. PubMed PMID: 28636814.

112:  Bao L, Wu J, Dodson M, Rojo de la Vega EM, Ning Y, Zhang Z, Yao M, Zhang DD, Xu C, Yi X. ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. Mol Carcinog. 2017 Jun;56(6):1543-1553. doi: 10.1002/mc.22615. Epub 2017 May 2. PMID: 28112439.

111:  Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang D. The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol. 2017 May 15;198(10):3927-3938. doi: 10.4049/jimmunol.1600312. Epub 2017 Apr 19. PubMed PMID: 28424240.

110:  Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD. Brusatol overcomes chemoresistance through inhibition of protein translation. Mol Carcinog. 2017 May;56(5):1493-1500. doi: 10.1002/mc.22609. Epub 2017 Feb 8. PMID: 28019675

109:  Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, Tillotson J, Chapman E, Zhang DD. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex. Mol Cell Biol. 2017 Mar 31;37(8). pii: e00660-16. doi:10.1128/MCB.00660-16. Print 2017 Apr 15. PubMed PMID: 28115426.

108:  de la Vega MR, Dodson M, Chapman E, Zhang DD. NRF2-targeted therapeutics: New targets and modes of NRF2 regulation. Curr Opin Toxicol. 2016 Dec;1:62-70. doi:10.1016/j.cotox.2016.10.005. Epub 2016 Oct 12.

107:  Wang S, Sun J, Zhang DD, Wong PK. A nanobiosensor for dynamic single cell analysis during microvascular self-organization. Nanoscale. 2016 Oct 14;8(38):16894-901. doi: 10.1039/c6nr03907c. PMID:27547924

106: Kong S, Yang Y, Xu Y, Wang Y, Zhang Y, Melo-Cardenas J, Xu X, Gao B, Thorp EB, Zhang DD, Zhang B, Song J, Zhang K, Zhang J, Zhang J, Li H, Fang D. Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proc Natl Acad Sci U S A. 2016 Sep 13:113(37):10394-9. doi: 10.1073/pnas.1606742113. PMID: 27573825

105: Wang H, Rojo de la Vega M, Zhang DD*, Yu S*, Zheng H*. Response to comment on "NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis". Sci Transl Med. 2016 Jul 27;8(349):349lr1. doi: 10.1126/scitranslmed.aag1805. PMID: 27464746

104: Xu Y, Zhao F, Qiu Q, Chen K, Wei J, Kong Q, Gao B, Melo-Cardenas J, Zhang B, Zhang J, Song J, Zhang DD, Zhang J, Fan Y, Li H, Fang D. The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun. 2016 Jul 15;7:12073. doi: 10.1038/ncomms12073. PMID: 27417417

103: de la Vega MR, Dodson M, Gross C, Manzour H, Lantz RC, Chapman E, Wang T, Black SM, Garcia JG, Zhang DD. Role of Nrf2 and Autophagy in Acute Lung Injury. Curr Pharmacol Rep. 2016 Apr;2(2):91-101. PMID: 27313980

102: Sun J, Hoying JB, Deymier PA, Zhang DD, Wong PK. Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility. PLoS Comput Biol. 2016 May 19;12(5):e1004955. doi: 10.1371/journal.pcbi.1004955. PMID: 27196735

101: Corenblum MJ, Ray S, Remley QW, Long M, Harder B, Zhang DD, Barnes CA, Madhavan L. Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period. Aging Cell. 2016 Aug: 15(4):725-36. Doi:10.1111/acel.12482. PMID: 27095375  

100: Tang Q, Liang M, Lu Y, Wong PK, Wilmink GJ, Zhang DD, Xin H. Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications. Sensors (Basel). 2016 Apr 4;16(4). pii: E476. doi: 10.3390/s16040476. PMID: 27049392

99: Wang H, Liu X, Long M, Hunag Y, Zhang L, Zhang R, Zheng Y, Liao X, Wang Y, Liao Q, Li W, Tang Z, Tong Q, Wang X, Fang F, Long M, Rojo de la Vega M, Ouyang Q, Zhang DD*, Yu S*, and Zheng H*. NRF2 activation by anti-diabetic agents accelerates tumor metastasis. Sci Transl Med. 2016 Apr 13;8(334):334ra51. doi: 10.1126/scitranslmed.aad6095. PMID: 27075625

98: Melo-Cardenas J, Zhang Y, Zhang DD, Fang D. Ubiquitin-specific peptidase 22 functions and its involvement in disease. Oncotarget. 2016 Jul 12;7(28):44848-44856. doi: 10.18632/oncotarget.8602. Review. PMID: 27057639

97: Wang Y, Wang Y, Zhang Z, Park JY, Guo D, Liao H, Yi X, Zheng Y, Zhang DD, Chambers SK, Zheng W. Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway. Oncotarget. 2016 Mar 1;7(9):10363-72. doi: 10.18632/oncotarget.7004. PMID: 26824415

96: Chen W, Li S, Li J, Zhou W, Wu S, Xu S, Cui K, Zhang DD, Liu B. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30(7):2500-10. doi: 10.1096/fj.201500109R. Epub 2016 Mar 22. PMID: 27006451

95: Klionsky DJ, Abdelmohsen K, Abe A, et. al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. No abstract available. PMID: 26799652

94: Tao S, Rojo de la Vega M, Quijada H, Wondrak GT, Wang T, Garcia JG, Zhang DD. Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner. Sci Rep. 2016 Jan 5; 6:18760. doi: 10.1038/srep18760. PMID: 26729554

93: Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou S, Wong PK, Wondrak GT, Zheng H, Zhang DD. An Essential Role of NRF2 in Diabetic Wound Healing. Diabetes. 2016 Mar;65(3):780-93. doi: 10.2337/db15-0564. PMID:26718502

92: Yin YW, Jin HJ, Zhao W, Gao B, Fang J, Wei J, Zhang DD, Zhang J, Fang D. The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer. Gene Expr. 2015; 16(4):187-96. doi: 10.3727/105221615X14399878166230. PMID: 26637399

91: Qian Z, Zhou T, Gurguis CI, Xu X, Wen Q, Lv J, Fang F, Hecker L, Cress AE, Natarajan V, Jacobson JR, Zhang DD, Garcia JG, Wang T. Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival. Sci Rep. 2015 Nov 24;5:16889. doi: 10.1038/srep16889. PMID: 26596768

90: Tao S, Park SL, de la Vega MR, Zhang DD, Wondrak GT. Systemic administration of the pocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2. Free Radic Biol Med. 2015 Oct 16;89:690-700. doi: 10.1016/j.freeradbiomed.2015.08.028. [Epub ahead of print] PMID: 26456052

89: Wang S, Riahi R, Li N, Zhang DD, Wong PK. Biosensors: Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments (Adv. Mater. 39/2015). Adv Mater. 2015 Oct;27(39):6076. doi: 10.1002/adma.201570265. PMID: 26466935

88: Jiang T, Harder B, Rojo de la Vega M, Wong PK, Chapman E, Zhang DD. P62 links the Nrf2 and autophagy pathways. Free Radic Biol Med. Free Radic Biol Med. 2015 Nov;88(Pt B):199-204. doi: 10.1016/j.freeradbiomed.2015.06.014. Epub 2015 Jun 24

87: Harder B, Jiang T, Wu T, Tao S, Rojo de la Vega M, Chapman E, Zhang DD. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochem. Soc. Trans. 2015 43(4):680-86.

86: Tao S, Tillotson J, Wijeratne EM, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, La Clair JJ, Gunatilaka AA, Zhang DD* and Chapman E*. Withaferin A Analogs That Target the AAA+ Chaperone p97. ACS Chem Biol. 2015. doi: 10.1021/acschembio.5b00367

         85: Shen T, Jiang T, Long M, Chen J, Ren D, Wong PK, Chapman E, Zhou B and Zhang DD. A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response. Antioxid Redox Signal. 2015 doi: 10.1089/ars.2014.6074

84: Riahi R, Sun J, Wang S, Long M, Zhang DD, Wong PK. Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration. Nat Commun. 2015 Mar 13;6:6556. doi: 10.1038/ncomms7556. PubMed PMID: 25766473; PubMed Central PMCID: PMC4380165.

83: Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD*, Wondrak GT*. Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res (Phila). 2015 Feb 23. pii: canprevres.0359.2014. [Epub ahead of print] PubMed PMID: 25712056.

82: Bao L, Jaramillo MC, Zhang Z, Zheng Y, Yao M, Zhang DD, Yi X. Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells. Mol Med Rep. 2015 Jan;11(1):91-8. doi: 10.3892/mmr.2014.2671. Epub 2014 Oct 16. PubMed PMID: 25322694; PubMed Central PMCID: PMC4237096.

81: Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ. Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene. Drug Metab Dispos. 2015 Jan;43(1):93-9. doi: 10.1124/dmd.114.060103. Epub 2014 Oct 27. PubMed PMID: 25349122; PubMed Central PMCID: PMC4279086.

80: Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Oncogenic KRAS confers chemoresistance by upregulating NRF2. Cancer Res. 2014 Dec 15;74(24):7430-41. doi: 10.1158/0008-5472.CAN-14-1439. Epub 2014 Oct 22. PubMed PMID: 25339352; PubMed Central PMCID: PMC4268230.

79: Nam KH, Jamilpour N, Mfoumou E, Wang FY, Zhang DD, Wong PK. Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates. Sci Rep. 2014 Nov 7;4:6965. doi: 10.1038/srep06965. PubMed PMID: 25376886; PubMed Central PMCID: PMC4223667   


78: Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem. 2014 Sep 22;15(14):2125-31. doi: 10.1002/cbic.201402258. Epub 2014 Aug 14. PubMed PMID: 25125376; PubMed Central PMCID: PMC4187115. 


77: Wu T, Harder BG, Wong PK, Lang JE, Zhang DD. Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy? Mol Carcinog. 2014 Aug 23. doi: 10.1002/mc.22202. [Epub ahead of print] PubMed PMID: 25154499.               

76: Riahi R, Wang S, Long M, Li N, Chiou PY, Zhang DD, Wong PK. Mapping photothermally induced gene expression in living cells and tissues by nanorod-locked nucleic acid complexes. ACS Nano. 2014 Apr 22;8(4):3597-605. doi: 10.1021/nn500107g. Epub 2014 Mar 19. PubMed PMID: 24645754; PubMed Central PMCID: PMC4004321.

75: Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 2014 Apr 1;28(7):708-22. doi: 10.1101/gad.238246.114. Epub 2014 Mar 17. PubMed PMID: 24636985; PubMed Central PMCID: PMC4015486.

74: Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondrak GT, Ren DM, Zhang DD. Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway. Planta Med. 2014 Mar;80(5):426-34. doi: 10.1055/s-0034-1368197. Epub 2014 Feb 28. PubMed PMID: 24585092; PubMed Central PMCID: PMC4393250. 


73: Riahi R, Long M, Yang Y, Dean Z, Zhang DD, Slepian MJ, Wong PK. Single cell gene expression analysis in injury-induced collective cell migration. Integr Biol (Camb). 2014 Feb;6(2):192-202. doi: 10.1039/c3ib40095f. PubMed PMID: 


72:
 Wu T, Wang XJ, Tian W, Jaramillo MC, Lau A, Zhang DD. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. Free Radic Biol Med. 2014 Feb;67:69-80. doi: 10.1016/j.freeradbiomed.2013.10.806. Epub 2013 Oct 17. PubMed PMID: 24140708; PubMed Central PMCID: PMC3945083.

71: 
Jiang T, Tian F, Zheng H, Whitman SA, Lin Y, Zhang Z, Zhang N, Zhang DD. Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response. Kidney Int. 2014 Feb;85(2):333-43. doi: 10.1038/ki.2013.343. Epub 2013 Sep 11. PubMed PMID: 24025640; PubMed Central PMCID: PMC3992978.             


70: Bao LJ, Jaramillo MC, Zhang ZB, Zheng YX, Yao M, Zhang DD, Yi XF. Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma. Int J Clin Exp Pathol. 2014 Mar 15;7(4):1502-13. eCollection 2014. PubMed PMID: 24817946; PubMed Central PMCID: PMC4014230.               


69: 
Qiao S, Tao S, Rojo de la Vega M, Park SL, Vonderfecht AA, Jacobs SL, Zhang DD, Wondrak GT. The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8. PubMed PMID: 24113242; PubMed Central PMCID: PMC3981748. 


68: 
Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal. 2013 Nov 10;19(14):1647-61. doi: 10.1089/ars.2012.5117. Epub 2013 Mar 21. PubMed PMID: 23394605; PubMed Central PMCID: PMC3809600. 


67:
 Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev. 2013 Oct 15;27(20):2179-91. doi: 10.1101/gad.225680.113. Review. PubMed PMID: 24142871; PubMed Central PMCID: PMC3814639.

66: Whitman SA, Long M, Wondrak GT, Zheng H, Zhang DD. Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res. 2013 Oct 15;319(17):2673-83. doi: 10.1016/j.yexcr.2013.07.015. Epub 2013 Jul 27. PubMed PMID: 23896025; PubMed Central PMCID: PMC3809009.


65:
 Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, Kaufman RJ, Yang WL, Lin HK, Zhang D, Perlman H, Thorp E, Zhang K, Fang D. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013 Sep 11;32(18):2477-90. doi: 10.1038/emboj.2013.183. Epub 2013 Aug 13. PubMed PMID: 23942232; PubMed Central PMCID: PMC3770952.

64: Riahi R, Dean Z, Wu TH, Teitell MA, Chiou PY, Zhang DD, Wong PK. Detection of mRNA in living cells by double-stranded locked nucleic acid probes. Analyst. 2013 Sep 7;138(17):4777-85. doi: 10.1039/c3an00722g. Epub 2013 Jun 17. PubMed PMID: 23772441; PubMed Central PMCID: PMC3736730.                       


63:
 Zhang DD. Bardoxolone brings Nrf2-based therapies to light. Antioxid Redox Signal. 2013 Aug 10;19(5):517-8. doi: 10.1089/ars.2012.5118. Epub 2013 Jan 11. PubMed PMID: 23227819; PubMed Central PMCID: PMC3704121.

62:
 Chen W, Wang H, Tao S, Zheng Y, Wu W, Lian F, Jaramillo M, Fang D, Zhang DD. Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell Cycle. 2013 Jul 15;12(14):2321-8. doi: 10.4161/cc.25404. PubMed PMID: 24067374; PubMed Central PMCID: PMC3755082.              


61:
 Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD. USP15 negatively regulates Nrf2 through deubiquitination of Keap1. Mol Cell. 2013 Jul 11;51(1):68-79. doi: 10.1016/j.molcel.2013.04.022. Epub 2013 May 30. PubMed PMID: 23727018; PubMed Central PMCID: PMC3732832               


60: 
Lau A, Zheng Y, Tao S, Wang H, Whitman SA, White E, Zhang DD. Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol. 2013 Jun;33(12):2436-46. doi: 10.1128/MCB.01748-12. Epub 2013 Apr 15. PubMed PMID: 23589329; PubMed Central PMCID: PMC3700105.                 

59: Lu Y, Gao J, Zhang DD, Gau V, Liao JC, Wong PK. Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading. Anal Chem. 2013 Apr 16;85(8):3971-6. doi: 10.1021/ac4004248. Epub 2013 Feb 27. PubMed PMID: 23445209; PubMed Central PMCID: PMC4102406.                       


58:
 Lau A, Whitman SA, Jaramillo MC, Zhang DD. Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway. J Biochem Mol Toxicol. 2013 Feb;27(2):99-105. doi: 10.1002/jbt.21463. Epub 2012 Nov 27. Review. PubMed PMID: 23188707; PubMed Central PMCID: PMC3725327.

57:
 Wu W, Qiu Q, Wang H, Whitman SA, Fang D, Lian F, Zhang DD. Nrf2 is crucial to graft survival in a rodent model of heart transplantation. Oxid Med Cell Longev. 2013;2013:919313. doi: 10.1155/2013/919313. Epub 2013 Feb 28. PubMed PMID: 23533698; PubMed Central PMCID: PMC3603380.                     

56: 
Ji L, Li H, Gao P, Shang G, Zhang DD, Zhang N, Jiang T. Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer. PLoS One. 2013 May 7;8(5):e63404. doi: 10.1371/journal.pone.0063404. Print 2013. PubMed PMID: 23667609; PubMed Central PMCID: PMC3646742.

55#:
 Tao S, Justiniano R, Zhang DD, Wondrak GT. The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV. Redox Biol. 2013 Oct 29;1:532-41. doi: 10.1016/j.redox.2013.10.004. eCollection 2013. PubMed PMID: 24273736; PubMed Central PMCID: PMC3836278.

         #(This paper was highlighted as the top story in Pulmonary Cell News 2.06. February 14, 2013).      

54 :
Lau A, Tian W, Whitman SA, Zhang DD. The predicted molecular weight of Nrf2: it is what it is not. Antioxid Redox Signal. 2013 Jan 1;18(1):91-3. doi: 10.1089/ars.2012.4754. Epub 2012 Jul 30. PubMed PMID: 22703241; PubMed Central PMCID: PMC3503463.

53: 
Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol. 2012 Dec 15;265(3):292-9. doi: 10.1016/j.taap.2012.08.028. Epub 2012 Sep 6. PubMed PMID: 22975029; PubMed Central PMCID: PMC3725323. 


52:
 Chen W, Jiang T, Wang H, Tao S, Lau A, Fang D, Zhang DD. Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxid Redox Signal. 2012 Dec 15;17(12):1670-5. doi: 10.1089/ars.2012.4674. Epub 2012 Jun 11. PubMed PMID: 22559194; PubMed Central PMCID: PMC3474188.              


51: 
Wang F, Tian F, Whitman SA, Zhang DD, Nishinaka T, Zhang N, Jiang T. Regulation of transforming growth factor β1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells. Eur J Cell Biol. 2012 Oct;91(10):774-81. doi: 10.1016/j.ejcb.2012.07.004. Epub 2012 Aug 27. PubMed PMID: 22951256.  


50: 
Hu Q, Zhang DD, Wang L, Lou H, Ren D. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem Toxicol. 2012 Jun;50(6):1927-32. doi: 10.1016/j.fct.2012.03.059. Epub 2012 Mar 23. PubMed PMID: 22465804.       


49:
 Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD, Fang D. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94. doi: 10.1016/j.molcel.2012.03.024. Epub 2012 Apr 26. PubMed PMID: 22542455.

48 :
Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN, Zhang DD, Xia B. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol. 2012 Apr;32(8):1506-17. doi: 10.1128/MCB.06271-11. Epub 2012 Feb 13. PubMed PMID: 22331464; PubMed Central PMCID: PMC3318596.

47:
 Riahi R, Yang Y, Zhang DD, Wong PK. Advances in wound-healing assays for probing collective cell migration. J Lab Autom. 2012 Feb;17(1):59-65. doi: 10.1177/2211068211426550. Review. PubMed PMID: 22357609. 


46: Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One. 2012;7(7):e41831. doi: 10.1371/journal.pone.0041831. Epub 2012 Jul 26. PubMed PMID: 22848625; PubMed Central PMCID: PMC3406086.

45# : Zheng H, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang D, Zhang DD. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes. 2011 Nov;60(11):3055-66. doi: 10.2337/db11-0807. PubMed PMID: 22025779; PubMed Central PMCID: PMC3198067.

         #(This paper was featured by Judy B. de Haan in the same issue 2683-4. PMID: 22025774).

44:
 Kong S, Kim SJ, Sandal B, Lee SM, Gao B, Zhang DD, Fang D. The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation. J Biol Chem. 2011 May 13;286(19):16967-75. doi: 10.1074/jbc.M111.218206. Epub 2011 Mar 22. PubMed PMID: 21454709; PubMed Central PMCID: PMC3089540. 


43: Sun Z, Wu T, Zhao F, Lau A, Birch CM, Zhang DD. KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response. Mol Cell Biol. 2011 May;31(9):1800-11. doi: 10.1128/MCB.05036-11. Epub 2011 Mar 7. PubMed PMID: 21383067; PubMed Central PMCID: PMC3133232.

42: Ren D, Villeneuve NF, Jiang T, Wu T, Lau A, Toppin HA, Zhang DD. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1433-8. doi: 10.1073/pnas.1014275108. Epub 2011 Jan 4. PubMed PMID: 21205897; PubMed Central PMCID: PMC3029730.                


41:
 Chen N, Yi X, Abushahin N, Pang S, Zhang D, Kong B, Zheng W. Nrf2 expression in endometrial serous carcinomas and its precancers. Int J Clin Exp Pathol. 2010 Dec 24;4(1):85-96. PubMed PMID: 21228930; PubMed Central PMCID: PMC3016106. 


40: Villeneuve NF, Lau A, Zhang DD. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211. Epub 2010 Aug 14. Review. PubMed PMID: 20486766; PubMed Central PMCID: PMC2966484.

39: Zhang DD. The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer. Antioxid Redox Signal. 2010 Dec 1;13(11):1623-6. doi: 10.1089/ars.2010.3301. Epub 2010 Aug 23. PubMed PMID: 20486759.

38: Chen HC, Gau V, Zhang DD, Liao JC, Wang FY, Wong PK. Statistical metamodeling for revealing synergistic antimicrobial interactions. PLoS One. 2010 Nov 11;5(11):e15472. doi: 10.1371/journal.pone.0015472. Erratum in: PLoS One. 2011;6(7). doi: 10.1371/annotation/d598d976-2604-429b-a76f-14aeca628a8e. Chen, Chia Hsiang [corrected to Chen, Hsiang Chia]. PubMed PMID: 21124958; PubMed Central PMCID: PMC2988685.

37# :
Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26. PubMed PMID: 20421418; PubMed Central PMCID: PMC2897585.

         #(This paper was highlighted in the editor’s choice in Science Signaling 3(128):199). 


36: Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, Zhang DD. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res. 2010 Jul 1;70(13):5486-96. doi: 10.1158/0008-5472.CAN-10-0713. Epub 2010 Jun 8. PubMed PMID: 20530669; PubMed Central PMCID: PMC2896449.

35:
 Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28;17(5):537-47. doi: 10.1016/j.chembiol.2010.03.013. PubMed PMID: 20534351.

34:
 Wondrak GT, Villeneuve NF, Lamore SD, Bause AS, Jiang T, Zhang DD. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Molecules. 2010 May 7;15(5):3338-55. doi: 10.3390/molecules15053338. PubMed PMID: 20657484; PubMed Central PMCID: PMC3101712.

33: 
Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, Zhang DD. The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes. 2010 Apr;59(4):850-60. doi: 10.2337/db09-1342. Epub 2010 Jan 26. PubMed PMID: 20103708; PubMed Central PMCID: PMC2844833. 


32: 
Chen CH, Lu Y, Sin ML, Mach KE, Zhang DD, Gau V, Liao JC, Wong PK. Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels. Anal Chem. 2010 Feb 1;82(3):1012-9. doi: 10.1021/ac9022764. PubMed PMID: 20055494; PubMed Central PMCID: PMC2821038. 


31:
 Villeneuve NF, Sun Z, Chen W, Zhang DD. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle. 2009 Oct 15;8(20):3255-6. Epub 2009 Oct 17. PubMed PMID: 19806015; PubMed Central PMCID: PMC3918967.

30: 
Chen A, Gao B, Zhang J, McEwen T, Ye SQ, Zhang D, Fang D. The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol. 2009 Oct;29(19):5348-56. doi: 10.1128/MCB.00407-09. Epub 2009 Aug 3. PubMed PMID: 19651900; PubMed Central PMCID: PMC2747983.

29:
 Jiang T, Huang Z, Chan JY, Zhang DD. Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):8-14. doi: 10.1016/j.taap.2009.06.010. Epub 2009 Jun 16. PubMed PMID: 19538980; PubMed Central PMCID: PMC2739886. 


28:
 Zhao F, Wu T, Lau A, Jiang T, Huang Z, Wang XJ, Chen W, Wong PK, Zhang DD. Nrf2 promotes neuronal cell differentiation. Free Radic Biol Med. 2009 Sep 15;47(6):867-79. doi: 10.1016/j.freeradbiomed.2009.06.029. Epub 2009 Jun 30. PubMed PMID: 19573594; PubMed Central PMCID: PMC2748111.

27: 
Sun Z, Huang Z, Zhang DD. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One. 2009 Aug 11;4(8):e6588. doi: 10.1371/journal.pone.0006588. PubMed PMID: 19668370; PubMed Central PMCID: PMC2719090.

26:
 Gidwani V, Riahi R, Zhang DD, Wong PK. Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis. Analyst. 2009 Aug;134(8):1675-81. doi: 10.1039/b906077d. Epub 2009 May 22. PubMed PMID: 20448937.

25#: Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, Zhang DD. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell. 2009 Jun 26;34(6):663-73. doi: 10.1016/j.molcel.2009.04.029. PubMed PMID: 19560419; PubMed Central PMCID: PMC2714804.

         #(This paper was featured by Michel B. Toledano in the same issue 637-639. PMID: 19560415). 

24:
 Sun Z, Chin YE, Zhang DD. Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol. 2009 May;29(10):2658-72. doi: 10.1128/MCB.01639-08. Epub 2009 Mar 9. PubMed PMID: 19273602; PubMed Central PMCID: PMC2682049.

23:
 Wang XJ, Zhang DD. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS One. 2009;4(5):e5492. doi: 10.1371/journal.pone.0005492. Epub 2009 May 8. PubMed PMID: 19424503; PubMed Central PMCID: PMC2675063.

22: 
Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD. Dual roles of Nrf2 in cancer. Pharmacol Res. 2008 Nov-Dec;58(5-6):262-70. doi: 10.1016/j.phrs.2008.09.003. Epub 2008 Sep 13. Review. PubMed PMID: 18838122; PubMed Central PMCID: PMC2652397.

21: 
Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect. 2008 Sep;116(9):1154-61. doi: 10.1289/ehp.11464. PubMed PMID: 18795156; PubMed Central PMCID: PMC2535615.

20:
 Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. 2008 Aug 15;45(4):385-95. doi: 10.1016/j.freeradbiomed.2008.04.023. Epub 2008 Apr 26. PubMed PMID: 18482591; PubMed Central PMCID: PMC3710742.

19:
 Wang Z, Gidwani V, Zhang DD, Wong PK. Separation-free detection of nuclear factor kappa B with double-stranded molecular probes. Analyst. 2008 Aug;133(8):998-1000. doi: 10.1039/b809113g. Epub 2008 Jun 24. PubMed PMID: 18645638.

18: 
Meserve D, Wang Z, Zhang DD, Wong PK. A double-stranded molecular probe for homogeneous nucleic acid analysis. Analyst. 2008 Aug;133(8):1013-9. doi: 10.1039/b804853c. Epub 2008 Jun 6. PubMed PMID: 18645642. 


17:
 Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD. Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol. 2008 Aug 1;230(3):383-9. doi: 10.1016/j.taap.2008.03.003. Epub 2008 Mar 12. PubMed PMID: 18417180; PubMed Central PMCID: PMC2610481.

16: 
Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis. 2008 Jun;29(6):1235-43. doi: 10.1093/carcin/bgn095. Epub 2008 Apr 15. PubMed PMID: 18413364; PubMed Central PMCID: PMC3312612.

15:
 Gao B, Lee SM, Chen A, Zhang J, Zhang DD, Kannan K, Ortmann RA, Fang D. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep. 2008 May;9(5):480-5. doi: 10.1038/embor.2008.37. Epub 2008 Mar 28. PubMed PMID: 18369366; PubMed Central PMCID: PMC2373369.

14: 
Wang XJ, Sun Z, Chen W, Eblin KE, Gandolfi JA, Zhang DD. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol. 2007 Dec 1;225(2):206-13. Epub 2007 Aug 7. PubMed PMID: 17765279; PubMed Central PMCID: PMC2610476.

13:
 Sun Z, Zhang S, Chan JY, Zhang DD. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol. 2007 Sep;27(18):6334-49. Epub 2007 Jul 16. PubMed PMID: 17636022; PubMed Central PMCID: PMC2099624.

12: 
Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev. 2006;38(4):769-89. Review. PubMed PMID: 17145701. 


11
: Ansell PJ, Lo SC, Newton LG, Espinosa-Nicholas C, Zhang DD, Liu JH, Hannink M, Lubahn DB. Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha. Mol Cell Endocrinol. 2005 Nov 24;243(1-2):27-34. Epub 2005 Sep 28. PubMed PMID: 16198475.


10: 
Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem. 2005 Aug 26;280(34):30091-9. Epub 2005 Jun 27. PubMed PMID: 15983046. 


9:
 Li X, Zhang D, Hannink M, Beamer LJ. Crystal structure of the Kelch domain of human Keap1. J Biol Chem. 2004 Dec 24;279(52):54750-8. Epub 2004 Oct 8. PubMed PMID: 15475350.

8:
 Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol. 2004 Dec;24(24):10941-53. PubMed PMID: 15572695; PubMed Central PMCID: PMC533977.

7:
 Li X, Zhang D, Hannink M, Beamer LJ. Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2346-8. Epub 2004 Nov 26. PubMed PMID: 15583386. 


6:
 Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol. 2003 Nov;23(22):8137-51. PubMed PMID: 14585973; PubMed Central PMCID: PMC262403.

5:
 Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003 Oct;23(20):7198-209. PubMed PMID: 14517290; PubMed Central PMCID: PMC230321.

4:
 Salnikow K, Davidson T, Kluz T, Chen H, Zhou D#, Costa M. GeneChip analysis of signaling pathways effected by nickel. J Environ Monit. 2003 Apr;5(2):206-9. PubMed PMID: 12729255.

3:
 Zhang DD, Hartsky MA, Warheit DB. Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats. Exp Lung Res. 2002 Dec;28(8):641-70. PubMed PMID: 12490038.

2:
 Sachdev S, Bagchi S, Zhang DD, Mings AC, Hannink M. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway. Mol Cell Biol. 2000 Mar;20(5):1571-82. PubMed PMID: 10669735; PubMed Central PMCID: PMC85341.

1:  Zhou D#, Salnikow K, Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 1998 May 15;58(10):2182-9. PubMed PMID: 9605764. 


      *Co-corresponding author

      #Zhou D. is the former name of Zhang DD